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PATHFAST™ - Emergency Marker

NT-proBNP Marker

Emergency Marker

Features

Diagnosis and assessment of severity of congestive heart failure (HF)

PATHFAST™ determines the quantity of hs Trop I, NTproBNP, D-Dimer, hsCRP, Myoglobin, CK-MB mass, BRAHMS PCT and Presepsin from one single whole blood sample. The quantitative data of the parallel analyses provide results within minutes, which facilitate the therapeutical decision. Basis for a safe diagnosis on-site for patients with acute coronary syndrome, suspected coronary heart insufficiency, venous thromboembolism, inflammation and myocardial injury .

PATHFAST™ NTproBNP is an immunoassay for the in vitro quantitative determination of N-terminal pro-B-type natriuretic peptide (NTproBNP) in anticoagulated whole blood and plasma on the PATHFAST™ analyzer. PATHFASTTM NTproBNP can be used as an aid in the diagnosis in patients suspicious for congestive heart failure, the detection left ventricular dysfunction of and in the assessment of the severity of congestive heart failure (CHF). PATHFAST™ NTproBNP can also be used in the risk stratification in patients with acute coronary syndromes (ACS) and congestive heart failure and for monitoring the therapy in patients with left ventricular dysfunction. NTproBNP allows rule out of heart failure due to consistent and very high negative predictive values and has also proven as a prognostic marker in severe sepsis and septic shock. In patients with stable coronary artery disease NTproBNP is strongly associated with the cardiovascular outcome. NTproBNP is valuable in the identification and exclusion of acute heart failure of dyspneic patients presenting in the emrgency department. NTproBNP is also related to the long-term outcome presenting in the emergency department with and without cardiovascular impairment. NTproBNP also identifies subjects with rheumatoid disease who are at risk for cardiovascular morbidity and mortality. Stdudies have shown that NTproBNP is useful as a simple non-invasive method of screening patients with arthritis before starting or continuing therapy with non steroidal anti-inflammatory drugs (NSAIDs).


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Quick and precise identification of biomarkers for heart failure

Cardiovascular disease, such as heart failure, must be diagnosed and treated with timely and accurate detection. Nt probnp marker is a solution to this through the provision of results within a period of less than 17 minutes, providing laboratories with the ability for quick and accurate testing. Quickness is critical in the enabling of patient management as well as treatment decision-making based on the most current available information.

Quick test results to improve patient care

The NT probnp marker can produce a quick result in 17 minutes, which is needed to reduce waiting time among patients and maximize the effectiveness of laboratory operations. Quick results of the test enable healthcare professionals to make effective decisions timely, leading to quicker intervention and improved patient care.

By adopting this marker, the labs can improve patient satisfaction in the form of reduced wait times and facilitate better clinical decision-making through near real-time access to critical biomarker data.

High sensitivity diagnostics

The Nt probnp marker possesses a low limit of detection as low as 15 pg/ml such that minute changes in Nt probnp levels will be precisely established. Such sensitivity plays an essential role in the diagnosis of heart failure at the earliest possible stage and in detecting cardiovascular condition changes.br/>
With that degree of sensitivity, the NT probnp marker makes accurate diagnoses possible such that physicians and scientists are able to detect even minor alterations in NT probnp levels and, in this way, enable patients to receive the most appropriate treatment on the basis of the most accurate information.

Advantages of laboratory use of the NT probnp marker

The Nt probnp biomarker is intended to optimize laboratory efficiency, reduce reagent use, and offer high performance. Laboratories that utilize this test biomarker will benefit from its rapid testing time, cost-effective reagent consumption, and reduced sample volume demand. These make it worthy of being the best option for cardiovascular health clinical diagnosis and research purposes.

Cost-effective and efficient testing

Nt probnp marker is designed for maximum performance. The marker requires only 100 μl of sample volume per test, conserving as much valuable sample as possible, and saving valuable specimen material while maintaining high test accuracy. The 60 assays per order pack size gives labs the option to run a high number of samples without having to repeatedly reorder, making it an economic option for high-throughput testing labs. It allows laboratories to utilize their resources optimally but achieve superior, consistent test results.

Flexible for research and clinical use

The Nt probnp marker is also very readable, possessing a large measurement range of 15 - 30,000 pg/ml and hence extremely useful in clinical practice as well as in research. Whether you are using the marker for screening for heart failure in heterogeneous patient populations or are conducting complex cardiovascular studies, this marker provides accurate measurement over a wide range of Nt probnp concentrations.

Its flexibility positions it well across a wide range of conditions, from early detection of heart failure right through to advanced stages, and from research lab to clinical trial use, with provision for a range of diagnostic and research protocols.

Low maintenance with extended calibration life

One of the standout features of the Nt Probnp marker is that it is more stable in terms of calibration. With a 28-day calibration cycle, the laboratory can anticipate consistent and reliable performance with little-level intervention. This feature reduces downtime and repeated recalibration, thereby making the laboratory more efficient.

Long-term consistency of performance

The 28-day calibration cycle permits the Nt probnp marker to provide accurate results in the long run, keeping maintenance processes to a minimum and having the equipment ready to perform at optimal capacity at all times. The long-term stability minimizes workflow interruptions to the lab, allowing the personnel to focus on testing and analysis without concerns about system maintenance. This marker is particularly handy to employ in high-throughput situations where time is of the essence and continuity in operations must be maintained.

Why use the NT probnp marker in your laboratory?

Phc Nt probnp marker offers numerous benefits that render it the best test for labs requiring efficient and precise testing for cardiovascular disease and heart failure. Fast results, high sensitivity, minimal volume sample requirements, and long life calibration provide this biomarker test to enhance diagnostic capability, improve patient outcomes, and boost lab productivity overall.

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Assay Specifications

Method Chemiluminescent Enzyme Immuno Assay - Magtration
Sample Material - Heparin-whole Blood
- Heparin-Plasma
- EDTA-whole Blood
- EDTA-Plasma
Sample Volume 100 μl
Reference Values See table below
Test Duration < 17 Minutes
Durability of Calibration 28 Days
Measurement Range 15 - 30 000 pg/m
Limit of Detection 15 pg/ml
Pack size 60 tests
Reference Values
Value in pg/ml Risk Stratification
< 125 Exclusion of ventricular dysfunction in patients with symptoms of CHF
< 300 Acute cardiac insufficiency improbably
 300 - 1800 Age dependent CutOff values

Age dependent CutOff values

Patient Age NTproBNP pg/ml
< 50 300 - 450
 > 450
50 - 75 300 - 900  > 900
> 75 300 - 900  > 1800
  Acute cardiac insufficiency improbably Acute cardiac insufficiency probably

* for more detailed information, please refer to the instruction for use, delivered with each reagent

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